Consistent with this role, ANO1 has been found to be upregulated in experimental models with circulatory abnormalities, for example, pulmonary and essential hypertension (Askew Page et al., 2019; Forrest et al., 2012; Gui et al., 2015; Papp et al., 2019; Wang et al., 2015). This evidence concerns the gene ANO1 and hypertensive disorder.