EIF6 and cancer: Since eIF6 recruitment to the nucleolus is dependent on BCCIP (Figure 4) and mutations in the NAS-2 region were sufficient to abrogate eIF6 recruitment to the nucleolus and ribosome biogenesis (Figure 5), we tested the interaction between eIF6 and a panel of BCCIP mutants, including cancer relevant variants deposited in the TCGA database.