Our approach was to evaluate candidate small molecules for their effects on SARS-CoV-2 infectivity factors such as ACE2, and TMPRSS2 expression while monitoring their impact on host immune suppressors of viral infection (Natural Killer cells and TRAIL-mediated cell killing) and cytokine release that has been correlated with COVID-19 disease severity. The gene discussed is TNFSF10; the disease is COVID-19.