Although it has been demonstrated that p53 modulated TLR expression in cancer cells [62] and that TLR4 and TLR2 are involved in the apoptosis of neural cells [63, 64], we were previously unable to highlight a direct role of TLR2 and TLR4 in mediating anti-apoA-1 antibody apoptotic effect in U251 and SUPT1 [14, 15]. This evidence concerns the gene TP53 and cancer.