APOA1 and cancer: Our investigation started based on the observation that the addition of anti-apoA-1 IgGs in the cell culture medium induced a change over time in cell morphology of cancer-derived cell lines from different genetic background (Hela, U251, SUPT1), but not primary cells (macrophages or HAEC) nor immortalized cell lines (HEK293), whereas the isotype control IgGs had no visible effect.