TNFRSF8 and neoplasm: Among them, TNF receptor super family 8 (TNFRSF8 or CD30) and TNFRSF10D (TRAIL Receptor), together with two TNFRSF ligands TNFSF9 (CD137Ligand) and TNFSF4 (Ox40 Ligand) were notably up-regulated and some link to caspase 3-dependent tumor apoptosis have been described for TNFRSF8 (CD30) [56–58] and for TNFSF9 [59, 60], the lastest being also involved in promoting neuronal cell death [61].