TP53 and breast carcinoma: When considering families with the exclusive occurrence of female breast cancer, the analysis revealed that (likely) deleterious TP53g mutations as well as variants of uncertain significance were much more frequent in families with bilateral compared to families with unilateral breast cancer (TP53mut: 1.1% vs. 0.3%; TP53-VUS: 1.4% vs. 0.9%) (Table 4).