Altogether, the fact that neurons strongly depend on autophagy and autophagy is involved in the metabolism of the amyloidogenic proteins (Aβ and tau) together with the observation that herpesviruses dysregulate autophagic pathways could indeed suggest a possible indirect link between herpesvirus infection and amyloid-associated pathology in AD. The gene discussed is MAPT; the disease is Herpesviridae infectious disease.