<b>Results:</b> The current meta-analysis found a significant association between <i>PCSK9</i> gene E670G polymorphism and CAD under allelic (OR = 1.79, 95% CI = 1.42-2.27, <i>P</i> = 1.00 × 10<sup>-6</sup>), dominant (OR = 2.16, 95% CI = 1.61-2.89, <i>P</i> = 2.22 × 10<sup>-7</sup>), heterozygous (OR = 2.02, 95% CI = 1.55-2.64, <i>P</i> = 2.47 × 10<sup>-7</sup>), and additive genetic models (OR = 1.92, 95% CI = 1.49-2.49, <i>P</i> = 6.70 × 10<sup>-7</sup>). This evidence concerns the gene PCSK9 and coronary artery disorder.