On the other hand, the circulating levels of ALT [(SMD: 1.28 U/L; 95% CI 0.88, 1.69); P < 0.05), I2 = 94.8%, PHeterogenity = 0.000], AST [(SMD: 2.12 U/L; 95% CI 1.33, 2.98); P < 0.05), I2 = 98.08%, PHeterogenity = 0.000 ], LDH [(SMD: 4.06 U/L; 95% CI 2.77, 5.36); P < 0.05), I2 = 98.7%, PHeterogenity = 0.000 ], and TBil [(SMD: 1.13 U/L; 95% CI 0.42, 1.84); P = 0.002), I2 = 97.5%, PHeterogenity = 0.000 ] remained significantly higher in patients with severe COVID-19 following removal of larger sample sizes in the study, which included nearly 37% of the pooled sample size. Here, GPT is linked to COVID-19.