Remarkably, pooled analyses significantly demonstrated higher levels of ALT [(SMD: 1.40 U/L; 95% CI 0.93, 1.88); P < 0.05), I2 = 96.5%, PHeterogenity = 0.000 ] (Figure 2a), AST [(SMD: 2.11 U/L; 95% CI (1.40, 2.83); P < 0.05), I2 = 97.9%, PHeterogenity = 0.000] (Figure 2b), and LDH [(SMD: 3.88 U/L; 95% CI (2.70, 5); P < 0.05), I2 = 98.7%, PHeterogenity = 0.000] (Figure 2c) in patients with severe COVID-19 compared to non-severe COVID-19. Here, GPT is linked to COVID-19.