Q2-3, a synthetic dihydrobenzofuran lignan that stimulates production of IL-25, which competes with IL-17B for the IL-17RB receptor, reduces myeloid derived suppressor cell infiltration and metastasis appearance in a mouse model of breast cancer (168), suggesting its potential application to prevent breast cancer metastasis in humans (Table 2). The gene discussed is IL17B; the disease is breast cancer.