As IL-17B, IL-17C, IL-17E, and IL-17F also exploit the subunit IL-17RA to deliver their intracellular signals, mice selectively deficient for either these cytokines or the IL-RC, IL-RB, and IL-RE will help in better understating the role of the different cytokines of the IL-17 family in the microbiota-immunity-cancer axis. The gene discussed is IL25; the disease is cancer.