CRP and COVID-19: In summary, approximately 20% of COVID-19 patients with mild-moderate disease progress to severe-critical disease and this percentage is approximately 40% for the high-risk subgroup ≥65 years of age with co-morbidities or laboratory parameters indicative of systemic inflammation such as high levels of CRP, LDH, and ferritin or a dysfunction of the coagulation system as evidenced by elevated D-dimer levels (Uckun, 2020a).