Given the potent neurodifferentiating activity of CAPE, we next aimed to examine its effect on the WT and UAS-GAL4 [F1 progeny flies susceptible for AD, produced by crossing UAS-Tau R406W flies (AD model) with the ELAV-GAL4 strain flies] models of Drosophila (Figure 4A). The gene discussed is SMC2; the disease is Alzheimer disease.