ADAM10 and Alzheimer disease: As shown in Figure 3, Mn treatment significantly increased protein levels of β-secretase 1 BACE1 in the cerebral cortex and hippocampus of 3×Tg-AD mice (p < 0.05, t-test; Figures 3A,B); in contrast, protein levels of ADAM10 in the cortex and hippocampus of 3×Tg-AD mice were decreased significantly after Mn treatment (n = 5, p < 0.05, t-test; Figures 3A,C).