Additionally, proinflammatory cytokines, especially IL-1β elevation has been detected in AD patients (Cacabelos et al., 1991; Griffin et al., 2000; Forlenza et al., 2009) and in the brains of aged AD model mice (Lim et al., 2000; Ghosh et al., 2013). This evidence concerns the gene IL1B and Alzheimer disease.