SOD1 and amyotrophic lateral sclerosis: In this study, we have explored the impact of NMD on SOD1 and shown that the activity of the NMD pathway is of broad importance for ALS caused by PTC in SOD1. Through a large-scale analysis of human cancer exomes and transcriptomes we were able to confirm that SOD1 standardly obeys to the NMD pathway and its rules.