The highest tertile of galectin-1 remained independently associated with the occurrence of MACE after adjustment for age, sex, hypertension, diabetes, heart failure, peripheral artery disease, the usage of clopidogrel or ACEi/ARB, serum levels of hemoglobin, creatinine, hs-CRP, LVEF, SYNTAX score, MVD, and revascularization with PCI or CABG (aHR 10.95, 95% CI 2.29–52.47, p = 0.003). Here, LGALS1 is linked to diabetes mellitus.