Stimulation of NSCLC cells with TGFβ1 induced the expression of TGFβRI, and a small-molecule TNIK inhibitor, NCB-0846, downregulated the TGFBR1 gene expression and inhibited the TGFβ1-induced EMT of NSCLC cells. The gene discussed is TNIK; the disease is non-small cell lung carcinoma.