Indeed, inflammatory response genes encoding IL-8, IL-6R, NFKBIZ, IL-1R, and PTGS2 were significantly upregulated in our RNA-seq data (SI 3) suggested that CBD-induced cleavage of caspase 7 and PARP1 might stimulate cellular inflammatory responses in HNSCC. Here, IL1R1 is linked to head and neck squamous cell carcinoma.