The HAT activator ISX939 induces Rgs16::GFP protein in approximately 90% early passage mouse primary PDA cells (50 uM ISX9, 5% FBS; Fig. 2I), and mRNA of the endogenous Rgs16 gene and the Rgs16::GFP transgene within 16 h of treatment (Fig. 2K). Here, TMPRSS11D is linked to Patent ductus arteriosus.