To extend this analysis, we surveyed Rgs16 expression compared to Kras oncogenic allele status in bulk RNAseq obtained from established cancer cell lines from human PDA and a variety of other human cancer cell lines (Supplementary Table S1), and human PDA tumors (TCGA) (Supplementary Figs. S2, S3). This evidence concerns the gene RGS16 and Patent ductus arteriosus.