IDH2 and central nervous system cancer: Glioma classification became more automated and systematic8,9 with the discovery of mutations in the isocitrate dehydrogenase (IDH) gene10 (IDH mutated, IDHmut)5 of non-gliobastomas, as compared to IDH wild type (IDHwt) glioblastomas11–13 and co-deletion of chromosome arms 1p/19q in oligodendroglioma14–16.