Immunohistochemistry assay (Fig. 4B,C) showed similar phenomenon that compared with sham group, the increased GLT-1 immunoparticles after the administration of sulbactam were significantly attenuated by SB203580 pretreatment either in SB203580 + sulbactam + sham and SB203580 + sulbactam + ischemia group. The gene discussed is SLC1A2; the disease is ischemia.