METTL3 and infection: Consistent with these findings, when we used reverse transcription coupled with quantitative PCR (qRT-PCR) to measure total viral mRNA levels over a time course of infection (Fig. 5d), we observed that early viral genes were only modestly (less than two-fold or not significantly) decreased by METTL3 knockdown, whereas viral late genes were significantly reduced (sometimes greater than 10-fold).