To determine if loss of METTL3 similarly increased IFNB1 and innate immune-related transcripts in our experiments, we used siRNA to knock down METTL3 for 48 h prior to infection with Ad5 either in the presence or absence of ruxolitinub, a JAK/STAT inhibitor that blocks signaling downstream of type-I interferons such as IFNβ (Fig. S4a). The gene discussed is IFNB1; the disease is infection.