Specifically, control bcCML cells were more likely to be located within vessels (Fig. 6c, white arrow heads) or clustered together near vascular branching points (Fig. 6c, yellow arrow heads), while shSdc1 cells could most frequently be found as isolated cells, adjacent to but outside of the vasculature (Fig. 6c, red arrow heads), resulting in a fivefold drop of Sdc1 knockdown leukemia cells in blood vessels (Fig. 6e). This evidence concerns the gene SDC1 and leukemia.