Importantly, the dependency on syndecan signaling was conserved: thus SDC1 knockdown led to a 12 fold reduction of colony-forming ability in both a human bcCML line and a human AML line (Fig. 5h–i, Supplementary Fig. 3f); expression of SDC1 and ITGB7 in these human cell lines was confirmed by qRT-PCR (Supplementary Fig. 3g). Here, ITGB7 is linked to acute myeloid leukemia.