MMP3 and esophageal squamous cell carcinoma: The results from chamber assay indicated that miR-515-3p exerted a significant inhibitory effect on the invasion and migration of ESCC cells, whereas overexpression of vimentin or MMP3 markedly restored the invasive and migration ability of miR-515-3p-overexpressing ESCC cells (Fig. 5b and Supplementary Fig. S7a).