Besides the role of CALR on the initiation of adaptive T-cell-mediated immunity downstream of ICD, we have recently demonstrated that CALR spontaneously exposed on the surface of malignant blasts from acute myeloid leukemia patients is associated with improved innate immunity as a consequence of improved interleukin 15 (IL15) trans-presentation to natural killer (NK) cells98,99. The gene discussed is IL15; the disease is acute myeloid leukemia.