CD274 and neoplasm: Thus, the clinical benefit from the PD-1/PD‐L1 blockade therapy in NSCLC treatment is limited, and the reactivation of PD-L1 expression in tumor cells could be a key factor for turning the cold tumor microenvironment into a ‘hot’ one.13 In this regard, identifying specific agents that show potentials to reactivate tumor PD-L1 expression may be critical in designing effective combinatory therapy regimens.12