NFKB1 and neoplasm: High level of ROS in tumor cells has been connected to the activation of NF-κB signaling in tumor inflammation.40–42 The intracellular ROS may enhance the phosphorylation of IκB and lead to the proteasomal degradation of IκB, which in turn induces the release and translocation of NF-κB to the nucleus to initiate transcription.