Contraction-stimulated GLUT-4 reallocation can, in part, counter-act the down-regulation seen in patients with reduced insulin sensitivity, such as patients with diabetes type 2.25 26 Hence, the association between sedentary behaviour and a higher HbA1c in the participants with DM might be partly explained by these mechanisms.26 27. The gene discussed is SLC2A4; the disease is type 2 diabetes mellitus.