PTEN and keloid: Yan et al. reported that transfected miR-21-5p mimic or inhibitor, respectively, increased or decreased the migration, invasion, and sphere-forming abilities of keloid keratinocytes, implicating the participation of PTEN and p-AKT in the miR-21-5p regulation on EMT phenotypes and stemness signatures of keloid keratinocytes, which might be accounted for the invasion and recurrence of keloid [68].