The CUDC-907, a dual inhibitor of PI3K/Akt/mTOR pathway and HDACs, inhibited cell proliferation, migration, invasion, and ECM deposition of in vitro cultured KFs and also suppressed collagen accumulation and disrupted the capillaries of keloid explants ex vivo and in vivo, with the promotion of the acetylation of histone H3 [59]. The gene discussed is AKT1; the disease is keloid.