Family E and individual H harboured two heterozygous nonsense variants in exon 6 of CRYBB1. In family E, a novel heterozygous variant at c.656G>A responsible for an AD congenital lamellar cataract, resulted in a premature translation stop codon at p.W219, located in the cytoplasmic carboxy-terminal region of CRYBB1. This evidence concerns the gene CRYBB1 and Alzheimer disease.