Given anti-DENV IgM responses shortly succeed viremia during a dengue infection, we concluded those either PCR+ for DENV RNA or anti-DENV IgM+ represent active dengue cases (83.1%, 6998/8425) while those anti-DENV PCR− and anti-DENV IgM− represent non-active dengue cases (misdiagnoses 16.9%, 1427/8425). The gene discussed is CD40LG; the disease is dengue disease.