Further investigation and validation of these results is warranted, with additional cytokines and chemokines, e.g., 4E-BP1, AXIN1, and MMP-1, in which the metabolite sphingosine 1‐phosphate is of particular interest as it is part of the sphingolipid pathway (enriched in both QFS and CFS compared to HC). This evidence concerns the gene EIF4EBP1 and myalgic encephalomeyelitis/chronic fatigue syndrome.