LPS activity correlates positively with serum total cholesterol as well as triglyceride concentrations and negatively with HDL cholesterol concentration.5 It is related to elevated C-reactive protein,5 insulin resistance and obesity.6 Moreover, endotoxemia associates with the risk of metabolic syndrome (MetS),5,6 predicts incident diabetes5 and is an independent risk factor for cardiovascular diseases (CVDs).7,8. The gene discussed is CRP; the disease is metabolic syndrome.