HP and metabolic syndrome: GlycA derive from glycan N-acetylglucosamine residues on enzymatically glycosylated acute-phase proteins, mainly α1-acid glycoprotein but also haptoglobin, α1-antichymotrypsin, and transferrin.34 It is a systemic inflammation marker and a predictor of several incident diseases including T2DM35 and CVD.36 In our study, LPS was strongly associated with GlycA, and the association was especially prominent in participants suffering from MetS.