AGT and aortic aneurysm: To satisfy this unmet need, non‐genetic approaches, particularly insults of the aorta with chemicals, such as angiotensin II (AngII; Rateri et al., 2014), calcium chloride (Ikonomidis et al., 2003), and elastase (Pope et al., 2015), have been developed to induce aortic aneurysm formation.