Mayer et al. [32] isolated anti-MOG antibodies from a patient cohort suffering from patients with different disease phenotypes, like acute disseminated encephalomyelitis (ADEM), transverse myelitis or optic neuritis, multiple sclerosis (MS), anti-aquaporin-4 (AQP4)-negative neuromyelitis optica (NMO) and chronic relapsing inflammatory optic neuritis (CRION) and compared the antibodies’ binding pattern to different MOG mutants. Here, AQP4 is linked to optic neuritis.