Antibody hGC33 to glypican-3, a membrane protein that is overexpressed on hepatocellular carcinoma cells, increased binding of sorafenib-loaded polyethylene glycol-b-PLGA polymer nanoparticles (hGC33-SFB-NP) to glypican-3 on the cancer cells. The gene discussed is GPC3; the disease is hepatocellular carcinoma.