Like free hGC33, nanodrug surface-modified hGC33 inhibited the proliferation of hepatoma cells not only by blocking Wnt-induced signal transduction in HepG2 and Huh-7 cells of expressing GPC3, but also by inhibiting Wnt3a-induced β-catenin and YAP signal transduction. Here, YAP1 is linked to hepatocellular carcinoma.