Furthermore, the application of specific antibody hGC33 against GPC3 molecules on HCC cell membrane can not only improve the delivery of nanodrug targeting in vitro and in vivo [18, 19], but also block Wnt and/or other signal pathways connected with GPC3, inhibit the proliferation and/or survival of cancer cells, and may achieve synergistic anti-tumor activity. The gene discussed is GPC3; the disease is hepatocellular carcinoma.