The mRNA expression of periostin is increased in hypertensive nephropathy tissues, and is closely related to blood creatinine, urine protein and renal blood flow, suggesting that periosin may reflect the severity of hypertensive nephropathy. After effective treatment, the protein expression of periosin in renal tissue is significantly reduced, and the contents of ET4 and E-selectin, the markers of the vascular endothelial dysfunction, have little change compared with that before, suggesting that periostin are more sensitive in reflecting the outcome of renal injury in hypertension. This evidence concerns the gene POSTN and hypertensive nephropathy.