It has been reported that epithelial-mesenchymal transition(EMT) can lead to tubulointerstitial fibrosis and the progression of diabetic nephropathy.In recent years, studies have found that TGF-β promotes the transformation of renal epithelial tissue to mesenchymal tissue in patients with diabetic nephropathy [53–56]. The gene discussed is TGFB1; the disease is diabetic kidney disease.