After adjustment for known confounders (including: renal function, left ventricular ejection fraction, concomitant valve disease, lung disease, atrial fibrillation, diastolic dysfunction, pulmonary hypertension, and right ventricular dysfunction), baseline NT‐proBNP levels outside this “sweet‐spot” range were the only factors independently associated with poor symptomatic response to TAVI. Here, NPPB is linked to pulmonary arterial hypertension.