NPPB and Myocardial fibrosis: In contrast, because natriuretic peptide levels correlate with the extent of LV hypertrophy,36, 37 and very low levels have been associated with myocardial injury,38, 39 it has been speculated that low circulating BNP/NT‐proBNP levels in patients with AS may represent an insufficiently developed compensatory mechanism for increased wall stress and vulnerability to irreversible myocardial fibrosis—a substrate for poor post‐TAVI outcomes.33