Secreted by the myocardium in response to increased mechanical wall stress, blood levels of BNP (brain natriuretic peptide) and its pro‐hormone NT‐proBNP (N‐terminal proBNP) correlate positively with severity of AS and symptom onset, and elevated levels tend to reflect advanced disease.10, 11, 12. Here, NPPB is linked to aortic stenosis.