In univariable analyses, baseline predictors of no improvement in NYHA functional class at 1 year were plasma NT‐proBNP >10 000 ng/L, NT‐proBNP <800 ng/L, concomitant chronic lung disease, at least moderate mitral regurgitation, pulmonary artery systolic pressure, and right ventricular dysfunction. This evidence concerns the gene NPPB and Mitral regurgitation.