In detail, all pivotal biotargets of puerarin to treat COVID‐19 were identified via bioinformatic determination, including EGFR, TNF, TP53, CASP3, RELA, FOS, CASP8, PTGS2, IL2, PRKCB, BCL2, PRKCA, NOS3 and PPARG. The gene discussed is PRKCA; the disease is COVID-19.