In detail, all pivotal biotargets of puerarin to treat COVID‐19 were identified via bioinformatic determination, including EGFR, TNF, TP53, CASP3, RELA, FOS, CASP8, PTGS2, IL2, PRKCB, BCL2, PRKCA, NOS3 and PPARG. Here, NOS3 is linked to COVID-19.