Therefore, the systemic effects of white (WAT) and brown adipose tissue (BAT) can be different, and adipogenesis including browning of adipose tissue and deficiency of anti-inflammatory adipocytokines was strongly associated with adipose triglyceride lipase augmentation, altered glucose homeostasis, resistance to insulin of skeletal muscles, increased cardiac myocyte apoptosis, and lowered survival and function of progenitor endothelial cells, which could significantly influence on HF development, as well as end-organ fibrosis and multiple comorbidities (21). This evidence concerns the gene DDHD2 and hydrops fetalis.