Specially, it was considered that osteomimicry was closely related to cancer metastasis to skeleton.(Rucci and Teti, 2018; Shupp et al., 2018) Once reaching the bone, cancer cells with osteomimicry feature could produce factors that directly [i.e., RANKL (receptor activator of nuclear factor kappa B ligand), IL-2β, IL-6, IL-11, and TNF-α] or indirectly (PTHrP, parathyroid hormone-related peptide) promote osteoclastogenesis and bone resorption (Rucci and Teti, 2018). The gene discussed is TNFSF11; the disease is cancer.