SPARC and cancer: Next, we pooled all the 20 cancer types and found that all the three markers were prognosticator of solid cancers (SPARC: HR = 1.10, 95% CI = [1.01, 1.20], p = 0.028; SPP1: HR = 1.25, 95% CI = [1.14, 1.36], p < 0.001; BGLAP: HR = 1.13, 95% CI = [1.04, 1.24], p = 0.005) (Figure 3).