In the present study, we found that BRAP expression was strongly correlated with DNMT1, DNMT2, DNMT3A, and DNMT3B expression in human pan-cancer, such as ACC, BLCA, BRCA, CESC, COAD, ESCA, GBM, HNSC, KIRP, LAML, LGG, LIHC, LUSC, OV, PAAD, PCPG, PRAD, SKCM, STAD, THCA, THYM, UCEC, and UVM. Here, DNMT3B is linked to cancer.