In intracellular adhesion molecule-1 (ICAM-1) knockout mice treated with TIM-1 antibody, the renal and spleen mRNA expressions of the Th1 chemokines CXCL9 and CXCL10 were reduced and ICAM-1 mediated the recruitment of leukocytes in glomerulonephritis (23). The gene discussed is ICAM1; the disease is glomerulonephritis.