The CAIX/CAXII specific small-molecule inhibitor, SLC-0111 (Pacchiano et al., 2011; Supuran, 2018) has shown promising effect on suppressing tumor growth and metastasis by itself and in combination with conventional chemotherapeutic drugs (Boyd et al., 2017; McDonald et al., 2019) or immune checkpoint inhibitors (Chafe et al., 2019). Here, CA9 is linked to neoplasm.