To survive the nutrient and oxygen deprivation caused by insufficient perfusion, tumor cells trigger hypoxia-inducible factor (HIF) signaling, which culminates in the stabilization and activation of the transcription factor, HIF1α or HIF2α, and alters the expression of several downstream targets to promote survival, tumor growth and progression (Xie and Simon, 2017). This evidence concerns the gene HIF1A and neoplasm.