One commonly used tumor cell line is the INS-1 cells, derived from a rat insulinoma induced by X-ray irradiation, which displays many characteristics of pancreatic beta-cells including high insulin content and their ability to respond to glucose fluxes (Asfari et al., 1992; Bonner et al., 2010; Jhun et al., 2013; Eto et al., 2014; Heaslip et al., 2014). This evidence concerns the gene INS and pancreatic insulinoma.