At the same time, the effect of dsRNA on TLR3 is a proven trigger of apoptosis and necroptosis (Seya et al., 2012) and upregulation of IL-17 and IL-22 in the psoriasis model is associated with a decrease in the expression of a RIPK-1, traditionally considered as a necroptosis component (Saito et al., 2018). The gene discussed is IL22; the disease is psoriasis.