For example, exposure to IL-17 and IL-22, interleukins, which are elevated in psoriasis (Kim and Krueger, 2015), caused the expression of stem markers p63, CD44, CD29, and CD49f in keratinocytes in vitro due to activation of the RAC1/MEC/ERK/NF-κB pathway (Ekman et al., 2019). Here, IL22 is linked to psoriasis.