An example of the latter strategy comes from Prasad et al. who developed manganese dioxide (MnO2) nanoparticles conjugated with albumin that react with endogenous H2O2 to produce O2, with the beneficial side effect of increasing the local pH to combat tumor acidosis, previously mentioned as a hallmark of the TME (Prasad et al., 2014). This evidence concerns the gene ALB and neoplasm.