In addition, the crosstalk between Mutp53 and the master inflammatory regulator NF-κB pathway has been largely implicated in modulating tumor development and migration (69, 72–74), through the upregulation of a cancer-related gene signature including CXC-chemokines, interleukins (ILs) and ECM-related genes (73–75). The gene discussed is NFKB1; the disease is cancer.