TP53 and neoplasm: The anti-tumor activity of COTI-2 is at least partially achieved by promoting the refolding and therefore the DNA binding capacity of mutp53, leading to the reactivation of wildtype p53 target genes including CDKN1A, PUMA, and NOXA. Besides, MAPK and mTOR pathways are also involved in COTI-2 induced apoptosis or senescence (80, 94, 95).