TP53 and head and neck squamous cell carcinoma: MK-1775 significantly elevated the efficacy of cisplatin, vorinostat (HADC inhibitor), or alisertib (aurora kinase A inhibitor) in HNSCC cells expressing high-risk mutp53 both in vitro and in vivo, while tumor cells bearing wildtype p53 displayed minimal response to MK-1775 (114–117).