Of notice, in brain lower grade glioma (LGG), most SIGLEC family genes were highly correlated with CD4+ T cell and negatively correlated with CD8+ T cell infiltration; in LIHC, LUAD, LUSC, PAAD, READ, SARC, SKCM, and stomach adenocarcinoma (STAD), most SIGLEC family genes were positively correlated with CD8+ T cells. This evidence concerns the gene CD4 and gastric adenocarcinoma.