In LIHC and pancreatic adenocarcinoma (PAAD), only one (SIGLEC6) and three (SIGLEC2, SIGLEC15, and SIGLEC16) SIGLEC family genes were related to patients’ OS, respectively; however, when it comes to PFS, most SIGELC family genes changed to protective and risk factors in LIHC and PAAD, correspondingly. The gene discussed is SIGLEC15; the disease is pancreatic adenocarcinoma.