SIGLEC family genes (SIGLEC1 or CD169, SIGLEC2 or CD22, SIGLEC3 or CD33, SIGLEC4 or MAG, SIGLEC5, SIGLEC6, SIGLEC7, SIGLEC8, SIGLEC9, SIGLEC10, SIGLEC11, SIGLEC14, SIGLEC15, SIGLEC16) were also expressed in tumor cells, and we used the cBioPortal database to find mutation status of SIGLEC family genes in different cancer types. The gene discussed is CD33; the disease is neoplasm.