Using TIMER 2.0 to examine the correlation between SIGLEC family genes and six types of infiltrating immune cells (B cell, CD4+ T cell, CD8+ T cell, myeloid dendritic cell, macrophage, and neutrophil), we found in specific tumors, such as HNSC, THCA, and THYM, SIGLEC family genes were negatively correlated with B cell and CD8+ T cell infiltration, while in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), esophageal carcinoma (ESCA), and KIRP, most SIGLEC family genes were positively correlated with B cell and CD8+ T cell (Figures 7A–C). Here, CD4 is linked to carcinoma of esophagus.