We found that extent of tumor resection (HR, 3.32; 95% CI, 1.74 to 6.33; P = 0.000), Ki-67 labeling index (HR, 2.30; 95% CI, 1.23 to 4.29; P = 0.009) and tumor recurrent status (HR, 4.81; 95% CI, 2.48 to 9.31; P = 0.000) were independent predictors of PFS (Table 2). This evidence concerns the gene MKI67 and neoplasm.