IGFBP3 and neoplasm: We previously published that cyclin G2 also interacted with Dapper 1 and lactate dehydrogenase A, which both further supported the role of cyclin G2 as tumor suppression (18, 19).To validate the findings here, we first extracted proteins from cyclin G2 overexpressing SCC-9 cells, and through the Co-IP experiment, we found that cyclin G2 did indeed interact with IGFBP3 (Figure 4A).