PTEN and acute lymphoblastic leukemia: It was not possible to test whether T-ALL cell lines could display different sensitivity to the drugs, depending on their PTEN status (+: HUT78, PEER, vs mutated: Jurkat, MOLT-16) as in our experience we never detected any correlation between the PTEN status and differences in mTORC1 activation or sensitivity to metabolic inhibitors such as a blocker of the Essential Amino Acid transporter that affects constitutive mTORC1 and induced leukemic cell death (16).