Although counter-intuitive at first glance, this study could suggest that the anti-leukemic effects of estradiol and tamoxifen could be mediated through the G protein-coupled Estradiol Receptor (GPER) and not via classical ER, that are not bound by TAM and not expressed in several T-ALL cell lines (29). The gene discussed is GPER1; the disease is acute lymphoblastic leukemia.