To further confirm whether these USP38‐regulated cytokines are responsible for the DSS‐induced colitis in USP38‐KO mice, we neutralized IL‐6 and IL‐23 by peritoneal injection of anti‐IL‐6/IL‐23 antibodies (Abs) in WT or USP38‐KO colitis mice. Here, IL6 is linked to colitis.